Open Letter to UK MPs

Note as you read this letter that it makes clear the reality that oxidative stress precedes “HIV expression”. If HIV were really the cause or the primary cause of AIDS then the reverse would be true. Reverse or eliminate oxidative stress and you prevent AIDS.

Dear Sir/Madam

This letter comes to you on behalf of all those dehumanised people given an HIV positive death sentence. The system has rendered positive people mere components of a commercialised medical process. This is because we are denied the fundamental right to make informed choices in areas relating to medication and basic human rights. In particular, the establishment can offer only toxic drugs. A whole extra dimension of effective, non-toxic and inexpensive treatment is shut off for us because there is no NHS provision. This letter is an appeal to support the right of access of HIV positives to non-toxic, immune enhancing treatments by campaining and also by promoting our forthcoming meeting giving information on this. It is scandalous that after spending hundreds of billions of dollars on AIDS research the possibility of protecting and boosting the immune system rather than combating HIV receives very little attention. Did you know that the anti-HIV nucleoside analogue drugs suppress the bone marrow where all immune system cells are born? Here, for example, is a quote from the Adverse Drug Reaction Bulletin, June 1996, No.178, p675-678:

Page 675:

"The antiretroviral drugs currently licenced in the United Kingdom are zidovudine (azidothymidine), zalcitabine (ddC) and didanosine (ddI). All three are nucleoside analogues which are incorporated into different stages of viral nucleic acid replication within the infected host cell. ALL ARE VERY TOXIC. SUPPRESSION OF BONE MARROW ELEMENTS CAN OCCUR WITH ANY OF THE THREE, as can peripheral neuropathy"

It has been found that AIDS is characterised by a persistent oxidative imbalance. An increasing deficiency of the non-toxic anti-oxidant glutathione plays a crucial role in the transition from pre-AIDS to full blown disease (1,2) To quote from Montagnier (the discoverer of HIV) et al (3):

Page 655:

“A large body of data on in vitro human immunodeficiency virus (HIV) infection and biochemical clinical studies suggests that oxidative stress plays a role in AIDS pathogenesis*. Recent reports have implicated intracellular excess of reactive oxygen species (ROS) in the induction of HIV expression (4-7) and in the initiation of apoptotic cell death** (8). Studies showing a decrease in glutathione in peripheral blood mononuclear cells from symptom-free persons offer further evidence of a metabolic alteration leading to the decreased ability to counteract oxidative stress (9). These findings, together with other alterations of biochemical indicators of systemic oxidative damage that have been observed (10-12) suggest that antioxidants can be useful in inhibiting viral replication and cell death in patients with HIV infection and AIDS”

Page 662:

“It has been suggested that oxidative stress is a common mediator of apoptosis (8). This hypothesis stems from experimental evidence that oxidative stimuli induce apoptosis (13-15) while antioxidants inhibit it.”

“In AIDS pathogenesis oxidative stress is proposed as a metabolic alteration that favours disease progression by inducing both viral replication and apoptotic death”

Page 663:

“Indeed, evidence that oxidative stress induces, while antioxidants inhibit, HIV replication and apoptosis suggests the use of these molecules as an antiretroviral therapy to reduce cell death in AIDS patients”

This is more than just an academic issue, what we have is an ongoing violation of the health rights and well being of all HIV positive people. Thank you for your attention.

Yours sincerely

The London UK AIDS treatment discussion group

1.Droge and Holm (1997) Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J. 11:1077-1089

2. Herzenberg et al (1997) Glutathione deficiency is associated with impaired survival in HIV disease. Proc. Natl. Acad. Sci. USA 94:1967-1972

3. Montagnier et al (1997) Oxidative protein damage and degradation in lymphocytes from patients infected with human immunodeficiency virus. Journal of Infectious Diseases 176:655-64

4. Fauci et al (1991) Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester and N-acetyl cysteine. Proc. Natl. Acad. Sci. USA 88:896-990

5. Schreck et al (1991) Reactive oxygen intermediates as apparently widely used messengers in the activation of NF-kB transcription factor and HIV-1. EMBO J. 10:2247-58

6. Legrand-Poels et al (1990) Activation of human immunodeficiency virus type I by oxidative stress. AIDS Res. Hum. Retrovir. 6:1389-7

7. Roederer et al (1990) Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl cysteine. 87:4884-8

8. Buttke et al (1994) Oxidative stress is a mediator of apoptosis. Immunol. Today 15:7-10

9. Staal et al (1992) Glutathione deficiency and human immunodeficiency virus expression. Lancet 339:909-12

10. Cirelli et al (1991) Serum selenium concentration and disease progress in patients with HIV infection. Clin. Biochem. 24:211-4

11. Leff et al (1992) Progressive increase in serum catalase activity in advancing human immunodeficiency virus infection. Free Radic. Biol. Med. 13:143-9

12. Revillard et al (1992) Lipid peroxidation in human immunodeficiency virus infection. J. AIDS 5:637-8

13. Bonfoco et al (1995) Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. USA. 92:7162-6

14. Forrest et al (1994) Oxidative stress-induced apoptosis prevented by trolox. Free Radic. Biol. Med. 16:675-84

15. Levine et al (1994) H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response. Cell 79:583-93